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Epithalon (Epitalon/Epithalone)
For educational and research purposes only. Not medical advice.
Epithalon is the most studied telomerase-activating peptide. Khavinson's research shows telomere elongation in human cell cultures and potential lifespan effects in animal models. Clinical evidence is moderate — most studies are from Russian institutions.
Best Time
Evening (supports melatonin cycle)
Method
subcutaneous
Frequency
Daily for 10-20 days per cycle
Half-life
~2-3 hours
Cycle Length
10-20 day courses, 2-3x per year
Storage
Refrigerate at 2-8°C.
Published Dosing Ranges
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Contraindications
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Longevity stack — telomere support (Epithalon) + cellular repair and anti-aging gene activation (GHK-Cu). Complementary anti-aging mechanisms.
theoreticalEpithalon activates telomerase for telomere maintenance while SS-31 targets cardiolipin in mitochondrial membranes to restore bioenergetics. Nuclear + mitochondrial anti-aging from two independent pathways.
theoreticalSenolytic clearance of damaged cells (FOXO4-DRI) + telomerase activation to support remaining healthy cells (Epithalon). Sequential or parallel use for comprehensive anti-aging.
theoreticalExperimental gerontology 39 (10) :1499-511 · 2004-10-01
Bulletin of experimental biology and medicine 144 (6) :825-30 · 2007-12-01
Bulletin of experimental biology and medicine 137 (1) :78-81 · 2004-01-01
Bulletin of experimental biology and medicine 138 (1) :80-3 · 2004-07-01
Advances in gerontology = Uspekhi gerontologii 21 (1) :61-7 · 2008-01-01
Mechanism of Action
Activates telomerase, the enzyme that lengthens telomeres (the protective caps on chromosomes). Regulates melatonin production through pineal gland stimulation.
Reported by the community. These may not be supported by clinical evidence and are not medical recommendations.