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Copper Peptide GHK-Cu (Glycyl-L-Histidyl-L-Lysine:Copper(II))
For educational and research purposes only. Not medical advice.
GHK-Cu is one of the most well-studied skin and healing peptides. Naturally present in human plasma, it declines with age. Extensive in vitro and animal data shows collagen stimulation, wound healing, and gene regulation. Topical forms have the most human evidence.
Best Time
Evening (topical) for overnight repair
Method
topical
Frequency
1-2x daily (topical) or 2-3x/week (injectable)
Half-life
~1 hour (serum)
Cycle Length
Ongoing for topical, 8-12 weeks for injectable
Storage
Published Dosing Ranges
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Contraindications
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Both promote cell migration and wound healing through complementary mechanisms. TB-500 acts systemically while GHK-Cu provides local collagen and elastin support.
communityDual healing approach — GHK-Cu for collagen/elastin synthesis and gene regulation + Thymosin Beta-4 for cell migration and systemic repair. Popular in anti-aging protocols.
communityBPC-157's tissue repair pairs well with GHK-Cu's collagen and growth factor stimulation. Both promote angiogenesis through different pathways for comprehensive wound healing.
communityLongevity stack — telomere support (Epithalon) + cellular repair and anti-aging gene activation (GHK-Cu). Complementary anti-aging mechanisms.
theoreticalGHK-Cu's tissue remodeling and collagen induction combined with LL-37's antimicrobial defense and wound closure. Theoretical synergy for post-surgical or chronic wound recovery.
theoreticalJournal of biomaterials applications 37 (1) :132-150 · 2022-07-01
The American journal of sports medicine 54 (1) :223-229 · 2026-01-01
Frontiers in bioengineering and biotechnology 11 :1176352 · 2023-01-01
Antioxidants (Basel, Switzerland) 12 (4) · 2023-03-25
The Journal of clinical investigation 92 (5) :2368-76 · 1993-11-01
Mechanism of Action
Copper-binding tripeptide that activates wound healing genes, promotes collagen/elastin synthesis, has antioxidant and anti-inflammatory effects, and stimulates blood vessel and nerve growth.
Reported by the community. These may not be supported by clinical evidence and are not medical recommendations.