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FOXO4-D-Retro-Inverso Peptide
For educational and research purposes only. Not medical advice.
FOXO4-DRI is the most targeted senolytic peptide, selectively destroying senescent cells. Mouse studies showed reversal of age-related decline including improved kidney function and hair regrowth. Extremely early stage — high cost, limited human data.
Best Time
Morning
Method
subcutaneous
Frequency
3x per week for limited courses
Half-life
~6-8 hours
Cycle Length
3-6 courses, intermittent
Storage
Refrigerate at 2-8°C. Light-sensitive.
Published Dosing Ranges
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Contraindications
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FOXO4-DRI selectively triggers apoptosis in senescent cells (senolytic). Humanin is a mitochondrial-derived cytoprotective peptide that protects healthy cells. Complementary: clear damaged cells + protect healthy ones.
theoreticalSenolytic clearance of damaged cells (FOXO4-DRI) + telomerase activation to support remaining healthy cells (Epithalon). Sequential or parallel use for comprehensive anti-aging.
theoreticalNature communications 16 (1) :5672 · 2025-07-01
Communications biology 8 (1) :299 · 2025-02-24
JCI insight 6 (23) · 2021-12-08
Circulation 147 (8) :650-666 · 2023-02-21
Naunyn-Schmiedeberg's archives of pharmacology 396 (10) :2393-2403 · 2023-10-01
Mechanism of Action
Disrupts the FOXO4-p53 interaction in senescent cells, releasing p53 to trigger apoptosis. Selectively kills senescent ('zombie') cells while leaving healthy cells unaffected.
Reported by the community. These may not be supported by clinical evidence and are not medical recommendations.