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Elamipretide (SS-31/Bendavia/MTP-131)
For educational and research purposes only. Not medical advice.
SS-31 (Elamipretide) uniquely targets the inner mitochondrial membrane to restore function. Phase III trials for Barth syndrome and heart failure. Animal data shows reversal of age-related mitochondrial decline. One of the most promising longevity molecules.
Best Time
Morning
Method
subcutaneous
Frequency
Daily
Half-life
~4 hours
Cycle Length
4-12 weeks per clinical protocols
Storage
Refrigerate at 2-8°C.
Published Dosing Ranges
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Contraindications
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Both target mitochondrial function but differently — SS-31 stabilizes cardiolipin in the inner membrane while MOTS-c activates AMPK for metabolic homeostasis. Complementary mitochondrial support.
theoreticalEpithalon activates telomerase for telomere maintenance while SS-31 targets cardiolipin in mitochondrial membranes to restore bioenergetics. Nuclear + mitochondrial anti-aging from two independent pathways.
theoreticalJournal of the American Society of Nephrology : JASN 35 (6) :681-695 · 2024-06-01
Proceedings of the National Academy of Sciences of the United States of America 117 (26) :15363-15373 · 2020-06-30
Molecular biology reports 53 (1) · 2026-04-25
Kidney international 90 (1) :181-91 · 2016-07-01
Archives of biochemistry and biophysics 660 :137-148 · 2018-12-15
Mechanism of Action
Targets and stabilizes cardiolipin in the inner mitochondrial membrane. Improves electron transport chain efficiency, reduces reactive oxygen species (ROS), and restores mitochondrial function.
Reported by the community. These may not be supported by clinical evidence and are not medical recommendations.