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Mitochondrial Open Reading Frame of the 12S rRNA-c
For educational and research purposes only. Not medical advice.
MOTS-c is a novel mitochondrial peptide with exciting preclinical data showing metabolic benefits and exercise mimetic properties. Human data is limited to observational studies showing decreased levels with aging. Active research area.
Best Time
Morning
Method
subcutaneous
Frequency
3-5x per week
Half-life
~4 hours
Cycle Length
8-12 weeks
Storage
Refrigerate at 2-8°C.
Published Dosing Ranges
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Contraindications
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MOTS-c activates AMPK for metabolic optimization and exercise mimicry. AOD-9604 is an hGH fragment targeting fat metabolism. Complementary metabolic and lipolytic effects without GH receptor activation.
theoreticalBoth target mitochondrial function but differently — SS-31 stabilizes cardiolipin in the inner membrane while MOTS-c activates AMPK for metabolic homeostasis. Complementary mitochondrial support.
theoreticalAging 13 (2) :1692-1717 · 2021-01-19
Archives of cardiovascular diseases 115 (1) :48-56 · 2022-01-01
Diabetes & metabolism journal 46 (3) :402-413 · 2022-05-01
European review for medical and pharmacological sciences 26 (16) :5676-5682 · 2022-08-01
Frontiers in genetics 12 :685806 · 2021-01-01
Mechanism of Action
Mitochondria-derived peptide that activates AMPK, enhances glucose metabolism, promotes fatty acid oxidation, and improves insulin sensitivity. Acts as a mitochondrial signaling molecule.
Reported by the community. These may not be supported by clinical evidence and are not medical recommendations.