All information on this website is intended strictly for educational and research purposes only.
The content on OpenPep — including peptide profiles, clinical trial summaries, dosing information, and reconstitution calculators — must not be used for:
OpenPep aggregates publicly available clinical trial data and research. We do not sell, distribute, or recommend any substances. All AI-generated summaries are interpretations of published research and may contain errors.
Semax (Heptapeptide)
For educational and research purposes only. Not medical advice.
Semax is one of the most validated nootropic peptides globally. Approved in Russia for stroke recovery and cognitive enhancement with extensive clinical use. Increases BDNF significantly — the key growth factor for learning and memory.
Best Time
Morning and early afternoon
Method
nasal
Frequency
2-3x daily
Half-life
~3 minutes (rapid CNS effects)
Cycle Length
10-14 days, cycle off 1 week
Storage
Refrigerate at 2-8°C.
Published Dosing Ranges
Create an account to access peptide research data.
Contraindications
Create an account to access peptide research data.
The cognitive stack — Semax for stimulated focus (BDNF/dopamine) + Selank for calm focus (GABA/serotonin). Used together in Russian clinical practice for balanced nootropic effect.
documentedSemax upregulates BDNF and dopaminergic signaling for focus. PE-22-28 (Spadin) blocks TREK-1 potassium channels to enhance neuroplasticity and has antidepressant effects. Complementary cognitive mechanisms.
theoreticalDifferent neurotrophic mechanisms (BDNF vs HGF/c-Met). Theoretical compatibility but Dihexa is extremely potent and poorly studied. No data on combined safety profile.
theoreticalDSIP is a sleep-promoting peptide; Semax is a stimulating nootropic. Not inherently conflicting — used at different times (Semax AM, DSIP PM) — but theoretical concern about opposing neurological effects.
theoreticalBoth used clinically in Russia for neurodegenerative conditions. Semax provides neurotrophic factor stimulation while Cerebrolysin supplies bioactive neuropeptide fragments. Combined in clinical protocols for stroke recovery.
documentedPharmacotherapy 34 (5) :452-63 · 2014-05-01
Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury (5) :29-32 · 2013-01-01
Bioorganicheskaia khimiia 32 (2) :183-91 · 2006-01-01
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 105 (2) :35-40 · 2005-01-01
Eksperimental'naia i klinicheskaia farmakologiia 73 (4) :2-7 · 2010-04-01
Mechanism of Action
Synthetic analog of ACTH(4-10) that increases BDNF, NGF, and other neurotrophins. Enhances attention, memory, and learning through dopaminergic and serotonergic modulation.
Reported by the community. These may not be supported by clinical evidence and are not medical recommendations.