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Selank (Heptapeptide Anxiolytic)
For educational and research purposes only. Not medical advice.
Selank is an anxiolytic peptide with GABA-modulating properties that reduces anxiety without sedation. Approved in Russia for generalized anxiety. Often stacked with Semax for balanced cognitive enhancement — Selank provides calm while Semax provides stimulation.
Best Time
Morning and afternoon
Method
nasal
Frequency
2-3x daily
Half-life
~3 minutes (rapid CNS effects)
Cycle Length
14 days, cycle off 1 week
Storage
Refrigerate at 2-8°C.
Published Dosing Ranges
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Contraindications
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Selank's GABAergic anxiolytic effect + PE-22-28's TREK-1 blockade for antidepressant/neuroplasticity effects. Complementary mood and cognitive enhancement via distinct ion channel and receptor pathways.
theoreticalThe cognitive stack — Semax for stimulated focus (BDNF/dopamine) + Selank for calm focus (GABA/serotonin). Used together in Russian clinical practice for balanced nootropic effect.
documentedSelank's anxiolytic GABA modulation combined with DSIP's delta-wave sleep promotion. Anxiety reduction during the day + restorative sleep at night for cognitive recovery.
communityZhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 114 (7) :17-22 · 2014-01-01
Neuroscience and behavioral physiology 38 (2) :203-7 · 2008-02-01
Bioorganicheskaia khimiia 32 (2) :183-91 · 2006-01-01
Journal of clinical pharmacology 61 Suppl 2 :S114-S128 · 2021-08-01
Current medicinal chemistry 24 (34) :3711-3727 · 2017-11-17
Mechanism of Action
Synthetic analog of tuftsin that modulates GABA, serotonin, and dopamine systems. Provides anxiolytic effects without sedation, enhances memory consolidation, and has immunomodulatory properties.
Reported by the community. These may not be supported by clinical evidence and are not medical recommendations.