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The content on OpenPep — including peptide profiles, clinical trial summaries, dosing information, and reconstitution calculators — must not be used for:
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Vasoactive Intestinal Peptide
For educational and research purposes only. Not medical advice.
VIP is a key regulatory neuropeptide used extensively in functional medicine for CIRS (mold illness) per Dr. Ritchie Shoemaker's protocol. Also studied for pulmonary hypertension, IBD, and autoimmune conditions. FDA-approved as aviptadil (Zyesami) for ARDS.
Best Time
Morning, midday, evening, and bedtime
Method
nasal
Frequency
2-4x daily
Half-life
~1-2 minutes (rapid enzymatic degradation)
Cycle Length
30-90 days per Shoemaker protocol
Storage
Refrigerate at 2-8°C. Compound pharmacy preparation.
Published Dosing Ranges
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Contraindications
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Journal of evidence-based medicine 19 (1) :e70128 · 2026-03-01
Frontiers in immunology 17 :1669492 · 2026-01-01
Frontiers in psychology 17 :1768092 · 2026-01-01
2017-05-08
Mechanism of Action
Neuropeptide that acts on VPAC1/VPAC2 receptors. Regulates circadian rhythm, promotes vasodilation, modulates immune response, and has potent anti-inflammatory effects in the GI and respiratory tracts.
Reported by the community. These may not be supported by clinical evidence and are not medical recommendations.