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Protein Transduction Domain-Dishevelled Binding Motif
For educational and research purposes only. Not medical advice.
PTD-DBM is one of the only compounds shown to create genuinely new hair follicles via Wnt pathway activation. Mouse studies showed impressive hair regrowth. Very early stage — human trials limited. Potential game-changer for alopecia if clinical data confirms.
Best Time
Evening (overnight application)
Method
topical
Frequency
Daily
Half-life
Local action (topical)
Cycle Length
3-6 months
Storage
Room temperature in sealed container.
Published Dosing Ranges
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Contraindications
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The Journal of experimental medicine 212 (7) :1061-80 · 2015-06-29
Cells 12 (4) · 2023-02-09
Cells 14 (11) · 2025-05-26
Advanced healthcare materials 12 (18) :e2203094 · 2023-07-01
Mechanism of Action
Cell-penetrating peptide that activates the Wnt/β-catenin signaling pathway in hair follicle stem cells. Promotes hair follicle neogenesis (new follicle creation) rather than just existing follicle stimulation.
Reported by the community. These may not be supported by clinical evidence and are not medical recommendations.