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Ibutamoren Mesylate
For educational and research purposes only. Not medical advice.
MK-677 is the most studied oral GH secretagogue with multiple human trials showing sustained GH/IGF-1 increases. Notable for improving sleep quality and bone density. Main concerns are insulin resistance with long-term use and increased appetite.
Best Time
Before bed (may cause drowsiness)
Method
oral
Frequency
Once daily
Half-life
~4-6 hours (effects last 24h)
Cycle Length
8-12 weeks or longer
Storage
Room temperature, dry place.
Published Dosing Ranges
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Contraindications
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Neurology 71 (21) :1702-8 · 2008-11-18
The Journal of clinical endocrinology and metabolism 86 (3) :1116-25 · 2001-03-01
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 14 (7) :1182-8 · 1999-07-01
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 38 (7) :1075-1086 · 2021-07-01
Neuroscience research 222 :104989 · 2026-01-01
Mechanism of Action
Non-peptide oral ghrelin receptor agonist that stimulates GH secretion. Produces sustained GH/IGF-1 elevation for up to 24 hours, increases appetite, and improves sleep quality.
Reported by the community. These may not be supported by clinical evidence and are not medical recommendations.