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Melanotan II
For educational and research purposes only. Not medical advice.
Melanotan II is widely used for tanning and libido but has significant safety concerns. Non-selective melanocortin activation causes nausea, mole changes, and unpredictable skin darkening. PT-141 (Bremelanotide) was developed from MT-II as a more selective alternative.
Best Time
Before UV exposure (for tanning) or before bed
Method
subcutaneous
Frequency
Loading: daily for 1-2 weeks, then maintenance
Half-life
~33 minutes
Cycle Length
Loading 2 weeks, then 1-2x/week maintenance
Storage
Published Dosing Ranges
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Contraindications
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The Journal of clinical endocrinology and metabolism 90 (1) :219-24 · 2005-01-01
Journal of medicinal chemistry 61 (9) :4263-4269 · 2018-05-10
Experimental eye research 218 :108986 · 2022-05-01
Journal of muscle research and cell motility 35 (5-6) :279-93 · 2014-12-01
Journal of visualized experiments : JoVE (202) · 2023-12-01
Mechanism of Action
Non-selective melanocortin receptor agonist (MC1R-MC5R). Stimulates melanogenesis (tanning), increases libido through MC4R, and suppresses appetite through MC3R/MC4R.
Reported by the community. These may not be supported by clinical evidence and are not medical recommendations.