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Lys-Pro-Val (Alpha-MSH Fragment)
For educational and research purposes only. Not medical advice.
KPV is a potent anti-inflammatory tripeptide with strong preclinical evidence for IBD and inflammatory conditions. It works through NF-kB inhibition without melanocortin receptor side effects. Gaining popularity in functional medicine for gut health.
Best Time
With meals
Method
oral
Frequency
1-2x daily
Half-life
~2 hours
Cycle Length
4-8 weeks
Storage
Refrigerate at 2-8°C.
Published Dosing Ranges
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Contraindications
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KPV reduces intestinal inflammation via melanocortin pathways while Larazotide restores tight junction integrity to reduce intestinal permeability. Complementary gut barrier repair mechanisms.
theoreticalKPV (alpha-MSH fragment) suppresses NF-κB-driven inflammation while BPC-157 promotes tissue repair and angiogenesis. Popular gut-healing combination for inflammatory bowel conditions.
communityExperimental dermatology 28 (3) :219-224 · 2019-03-01
Gastroenterology 138 (3) :843-53.e1-2 · 2010-03-01
Nucleic acids research 39 (Database issue) :D677-84 · 2011-01-01
Oncogene 42 (25) :2074-2087 · 2023-06-01
PloS one 13 (6) :e0199686 · 2018-01-01
Mechanism of Action
C-terminal tripeptide fragment of alpha-MSH with potent anti-inflammatory activity. Inhibits NF-kB signaling, reduces inflammatory cytokines, and modulates immune response without melanocortin receptor activation.
Reported by the community. These may not be supported by clinical evidence and are not medical recommendations.