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Kisspeptin-10 (Metastin 45-54)
For educational and research purposes only. Not medical advice.
Kisspeptin-10 sits at the top of the reproductive hormone cascade. Clinical studies show it reliably stimulates GnRH/LH/FSH release and can restore reproductive function. Being studied for hypogonadism, IVF optimization, and sexual desire.
Best Time
Morning (mimics natural GnRH pulse)
Method
subcutaneous
Frequency
Variable (research protocols)
Half-life
~28 minutes
Cycle Length
Per research protocol
Storage
Refrigerate at 2-8°C.
Published Dosing Ranges
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Contraindications
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Pharmacological reviews 62 (4) :565-78 · 2010-12-01
Endocrinology 156 (12) :4639-48 · 2015-12-01
The Journal of neuroscience : the official journal of the Society for Neuroscience 29 (12) :3920-9 · 2009-03-25
PloS one 5 (9) :e12964 · 2010-09-23
The Journal of neuroscience : the official journal of the Society for Neuroscience 30 (25) :8581-90 · 2010-06-23
Mechanism of Action
Activates GPR54 (KISS1R) receptor in the hypothalamus, stimulating GnRH release which in turn triggers FSH and LH secretion. Master regulator of the reproductive axis.
Reported by the community. These may not be supported by clinical evidence and are not medical recommendations.