All information on this website is intended strictly for educational and research purposes only.
The content on OpenPep — including peptide profiles, clinical trial summaries, dosing information, and reconstitution calculators — must not be used for:
OpenPep aggregates publicly available clinical trial data and research. We do not sell, distribute, or recommend any substances. All AI-generated summaries are interpretations of published research and may contain errors.
Ipamorelin (Growth Hormone Secretagogue)
For educational and research purposes only. Not medical advice.
Ipamorelin is considered the safest and most selective growth hormone secretagogue. Human studies show clean GH pulses without cortisol or prolactin spikes. Popular as a foundational peptide for anti-aging and body composition optimization.
Best Time
Before bed (peak GH during sleep)
Method
subcutaneous
Frequency
1-3x daily
Half-life
~2 hours
Cycle Length
8-12 weeks, cycle off 4 weeks
Storage
Refrigerate at 2-8°C. Use within 21 days.
Published Dosing Ranges
Create an account to access peptide research data.
Contraindications
Create an account to access peptide research data.
FDA-approved GHRH analog (Tesamorelin) paired with the cleanest GHRP. Tesamorelin specifically reduces visceral adipose tissue while Ipamorelin adds GH pulsatility.
communityThe classic GH stack. GHRH (CJC-1295) + GHRP (Ipamorelin) produce synergistic GH release — 2-3x more than either alone. The most popular peptide combination.
documentedGHRH + GHRP synergy similar to CJC-1295/Ipamorelin stack. Sermorelin has a longer clinical safety record. Popular in anti-aging clinics.
documentedIpamorelin's clean GH pulse combined with DAC version's sustained release. Provides both acute spikes and elevated baseline. Requires careful dosing to avoid GH bleed.
communityGH release from Ipamorelin supports the tissue repair mechanisms of BPC-157. Popular combination for recovery-focused protocols.
communityDSIP promotes delta-wave sleep when GH secretion naturally peaks. Ipamorelin before bed amplifies the nocturnal GH pulse. Community-reported synergy for recovery and sleep quality.
communityEuropean journal of endocrinology 141 (2) :180-9 · 1999-08-01
The American journal of sports medicine 54 (1) :223-229 · 2026-01-01
Pharmaceutical research 16 (9) :1412-6 · 1999-09-01
Journal of separation science 39 (2) :333-41 · 2016-01-01
Drug testing and analysis 6 (10) :985-95 · 2014-10-01
Mechanism of Action
Selective growth hormone secretagogue that binds to ghrelin receptors in the pituitary, stimulating natural GH release without significantly affecting cortisol or prolactin levels.
Reported by the community. These may not be supported by clinical evidence and are not medical recommendations.